618: Methylation, Epigenetics & Longevity with Steve Horvath

Kane Tanaka of Japan died in 2022 at the age of 119. Lucile Randon of France died in 2023 at 118. Jiroemon Kimura of Japan died in 2023 at 116, the oldest male ever. What did these people have in common? Were they biohackers? Did they do CrossFit? Did they take NAD supplements or run marathons? Nope. Like almost all centenarians they lived exceptionally long lives most-likely due to genetics, combined with a moderately healthy or even average healthy lifestyle. Despite the overwhelming abundance of evidence that we’re all going die sooner rather than later, the quest for longevity never stops. My guest on this week’s podcast has developed a unique way to measure biological age and his work is playing a key role in longevity research and biohacker communities.

Listen and learn:

• The overlooked role of epigenetics in your health and lifespan
• Biohackers, science fiction, and the reality of living a long time
• How methylation patterns can be predictive of lifespan
• The significance of GrimAge for reducing early mortality 

Links

Steve on X

ABOUT OUR GUEST

Steve Horvath is a German-American researcher, geneticist, and biostatistician. He is a professor at UCLA and the principal investigator at Altos Labs, specializing in epigenetic biomarkers of aging, genomics, and comparative biology. 

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